|The AATF aatf (Catalog #MBS9407456) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AATF Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s AATF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western blotting: 1:500~1:3000. Researchers should empirically determine the suitability of the AATF aatf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The AATF aatf product has the following accession number(s) (GI #7657013) (NCBI Accession #NP_036270.1) (Uniprot Accession #Q9NY61). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the AATF Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from HeLa cells, HepG2 cells, COLO205 cells and HUVEC cells, using AATF antibody.)
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.Lindfors K., Biochem. Biophys. Res. Commun. 276:660-666(2000).Fanciulli M., FASEB J. 14:904-912(2000).Di Padova M., J. Biol. Chem. 278:36496-36504(2003).
Immunogen Type: Peptide
Immunogen Description: Synthesized peptide derived from N-terminal of human AATF. Target Name: AATF. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AATF are readily searchable from our website. Different antibodies against the same target such as AATF may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Prostate tissues are correlated with this protein. The following patways have been known to be associated with this gene. Breast Neoplasms, Cardiovascular Diseases, Cell Transformation, Neoplastic, Diabetes Mellitus, Inflammation, Liver Diseases, Liver Neoplasms, Liver Neoplasms, Experimental, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to AATF Antibody.