|The ABL1 abl1 (Catalog #MBS9411897) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ABL1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s ABL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western blotting: 1:500 - 1:2000. Researchers should empirically determine the suitability of the ABL1 abl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ABL1 abl1 product has the following accession number(s) (GI #62362414) (NCBI Accession #NP_005148.2) (Uniprot Accession #P00519). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ABL1 antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of various cell lines, using ABL1 antibody.)
The c-Abl proto-oncogene encodes a nonreceptor protein tyrosine kinase that is ubiquitously expressed and highly conserved in metazoan evolution. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. It is implicated in regulating cell proliferation, differentiation, apoptosis, cell adhesion and stress responses (1-3). c-Abl kinase activity is increased in vivo by diverse physiological stimuli including integrin activation, PDGF stimulation and binding to c-Jun, Nck and RFX1 (2,4). The in vivo mechanism of regulation of c-Abl kinase activity is not completely understood. Tyr245 is located in the linker region between the SH2 and catalytic domains. This positioning is conserved among Abl family members. Phosphorylation of Tyr245 is involved in the activation of c-Abl kinase (5). In addition, phosphorylation of Tyr412, which is located in the kinase activation loop of c-Abl, is required for kinase activity (6).
Immunogen Type: Peptide
Immunogen Description: C term -peptide of human ABL1. Target Name: ABL1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ABL1 are readily searchable from our website. Different antibodies against the same target such as ABL1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. ABL1 also interacts with the following gene(s): ABI1, ATM, BCR, CBL, CRKL, GRB2, RAD51, RB1. The following patways have been known to be associated with this gene.