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anti-ACAN antibody product blog

Posted on 2015-10-18 19:42:59 by mybiosource_staff
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Tags: Antibody; anti-ACAN antibody; ACAN; Polyclonal Antibody; Large Proteoglycan;
The ACAN acan (Catalog #MBS618312) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Large Proteoglycan (Versican, Chondroitin Sulfate Proteoglycan Core Protein 2, CSPG2, DKFZp686K06110, ERVR, Glial Hyaluronate Binding Protein, GHAP, Large Fibroblast Proteoglycan, PGM, V1 Neo, VCAN, Versican Core Protein, Versican Proteoglycan, Versican V reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Large Proteoglycan can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot.
Dilution: Western Blot: 1ug/ml. Detects a band at ~70kD. Researchers should empirically determine the suitability of the ACAN acan for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The ACAN acan product has the following accession number(s) (GI #178259) (NCBI Accession #AAA62824.1) (Uniprot Accession #P16112). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Versican is a large multi-domain chondroitin sulfate proteoglycan. It is secreted by fibroblasts and other types of cells. It has a N-terminal hyaluronic acid (HA) binding domain. This domain has homology with the G1 and G2 domains of aggrecan (G1 is the hyaluronic acid binding region), to cartilage link protein which stabilizes the binding of aggrecan to hyaluronic acid, and, to the hyaluronate receptor CD44. In addition, Versican also has a lectin-like domain, a C-terminal compliment repeat, and two EGF-like repeats, all of which can be found in aggrecan. Versican has an apparent molecular mass of ~1000kD, of which the core contributes 400kD from the 2409 amino acids, and the 12-15 covalently attached chondroitin sulfate chains make up the rest.

ACAN acan

Immunogen: Synthetic peptide corresponding to aa436-441, CGG-DPEAAE, of human Versican. Cellular Localization: Secreted, extracellular matrix. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACAN are readily searchable from our website. Different antibodies against the same target such as ACAN may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. ACAN also interacts with the following gene(s): ADAMTS4, BMP2, FMOD, KERA, LUM, SOX9.
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