|The ACLY acly (Catalog #MBS2522473) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ACLY Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s ACLY can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC).
IHC: 1:50-1:200. Researchers should empirically determine the suitability of the ACLY acly for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ACLY acly product has the following accession number(s) (GI #38569423) (NCBI Accession #NP_942127.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ACLY Polyclonal Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ACLY Polyclonal Antibody at dilution 1:40)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human brain tissue using ACLY Polyclonal Antibody at dilution 1:40)
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
Immunogen: Recombinant protein of human ACLY. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACLY are readily searchable from our website. Different antibodies against the same target such as ACLY may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Adenocarcinoma, Breast Neoplasms, Disease Models, Animal, Fatty Liver, Hyperlipidemias, Inflammation, Liver Diseases, Lung Neoplasms, Neoplasms, Experimental, Obesity are some of the diseases may be linked to ACLY Polyclonal Antibody. Adipose Tissue, Blood, Brain, Connective Tissue, Liver, Lung, Mammary Gland, Muscle, Prostate, Thyroid tissues are correlated with this protein. The following patways have been known to be associated with this gene. ACLY also interacts with the following gene(s): ACACA, ACO2, FASN, MLXIPL, SLC25A1.