|The ACTN1 actn1 (Catalog #MBS2528284) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ACTN1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s ACTN1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the ACTN1 actn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ACTN1 actn1 product has the following accession number(s) (GI #194097350) (NCBI Accession #NP_001123476.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ACTN1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of 1) 3T3, 2) PC-12, 3) Rat heart with Actinin-?1 Polyclonal Antibody.)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Mouse kidney tissue with Actinin-?1 Polyclonal Antibody.)
alpha-Actinin belongs to the spectrin family of cytoskeletal proteins. It was first recognized as an actin cross-linking protein, forming an antiparallel homodimer with an actin binding head at the amino terminus of each monomer. More recently, alpha-actinin has been shown to interact with a large number of proteins involved in signaling to the cytoskeleton including those involved in cellular adhesion, migration, and immune cell targeting (1). The interaction of alpha-actinin with intercellular adhesion molecule-5 (ICAM-5) helps to promote neurite outgrowth (2). In osteoblasts, interaction of alpha-actinin with integrins stabilizes focal adhesions and may protect cells from apoptosis (3). Isoforms 1 and 4 of alpha-actinin, which are non-muscle isoforms, are present in stress fibers, sites of adhesion and intercellular contacts, filopodia, and lamellipodia. The muscle isoforms 2 and 3 localize to the Z-discs of striated muscle and to dense bodies and plaques in smooth muscle (1).
Immunogen: Recombinant protein of human ACTN1
Observed Molecular Weight: 103kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACTN1 are readily searchable from our website. Different antibodies against the same target such as ACTN1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. ACTN1 also interacts with the following gene(s): PDLIM1, SRC, TGFB1, TTN, VCL, ZYX. Adenocarcinoma, Brain Diseases, Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Inflammation, Nephritis, Nervous System Diseases, Urinary Bladder Neoplasms are some of the diseases may be linked to ACTN1 Antibody.