|The ADAM10 adam10 (Catalog #MBS840624) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADAM10 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ADAM10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western blotting (1-4 ug/ml) and immunofluorescence (2-10 ug/ml). An 85 kDa band corresponding to the precursor form of ADAM10 can be detected. Jurkat and K562 cell lysates can be used as positive controls. However, the optimal conditions should be determined individually. Researchers should empirically determine the suitability of the ADAM10 adam10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ADAM10 adam10 product has the following accession number(s) (GI #2393947) (NCBI Accession #AAC51766). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Background: Proinflammatory cytokine tumor necrosis factoralpha (TNF-alpha) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-alpha, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-alpha, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
Immunogen: Synthetic peptide corresponding to residue surrounding amino acid 735 of human ADAM10. Handling: The antibody solution should be gently mixed before use. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ADAM10 are readily searchable from our website. Different antibodies against the same target such as ADAM10 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Hepatocellular, Cardiovascular Diseases, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, Necrosis, Neoplasm Metastasis, Skin Diseases are some of the diseases may be linked to ADAM10 Antibody.