|The ADAM17 adam17 (Catalog #MBS9412011) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADAM17 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ADAM17 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC).
Immunohistochemistry: 1:15-1:50. Researchers should empirically determine the suitability of the ADAM17 adam17 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ADAM17 adam17 product has the following accession number(s) (GI #73747889) (NCBI Accession #NP_003174.3) (Uniprot Accession #P78536). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ADAM17 Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/15.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/15.)
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
Immunogen Type: Recombinant Protein
Immunogen Description: Full length fusion protein. Target Name: ADAM17. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ADAM17 are readily searchable from our website. Different antibodies against the same target such as ADAM17 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Atherosclerosis, Breast Neoplasms, Carcinoma, Hepatocellular, Disease Models, Animal, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Neoplasm Invasiveness, Neoplasm Metastasis are some of the diseases may be linked to ADAM17 Antibody. Bone Marrow, Brain, Embryonic Tissue, Eye, Kidney, Liver, Lung, Muscle, Ovary, Prostate tissues are correlated with this protein. ADAM17 also interacts with the following gene(s): EGFR, ERBB2, ERBB4, NCSTN, NOTCH1, NOTCH3, PSEN2, TIMP3.