|The ADRA1B adra1b (Catalog #MBS2520095) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADRA1B Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s ADRA1B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).
IHC: 1:25-1:100. Researchers should empirically determine the suitability of the ADRA1B adra1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ADRA1B adra1b product has the following accession number(s) (GI #4501959) (NCBI Accession #NP_000670.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ADRA1B Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of 293T, PC3 and hela cell using ADRA1B Polyclonal Antibody at dilution of 1:500)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer using ADRA1B Polyclonal Antibody at dilution of 1:25)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human lung cancer using ADRA1B Polyclonal Antibody at dilution of 1:25)
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.
Immunogen: Synthetic peptide of human ADRA1B
Calculated Molecular Weight: 57kDa. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ADRA1B are readily searchable from our website. Different antibodies against the same target such as ADRA1B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Arrhythmias, Cardiac, Cardiomegaly, Disease Models, Animal, Heart Diseases, Heart Failure, Hyperplasia, Hypertension, Hypertrophy, Hypotension, Pain are some of the diseases may be linked to ADRA1B Polyclonal Antibody.