anti-ADRA2C antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-ADRA2C antibody; ADRA2C;
The ADRA2C adra2c (Catalog #MBS9206885) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADRA2C Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. MyBioSource\'s ADRA2C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC).WB~~1:1000. Researchers should empirically determine the suitability of the ADRA2C adra2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ADRA2C adra2c product has the following accession number(s) (GI #71773208) (NCBI Accession #NP_000674.2) (Uniprot Accession #P18825). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ADRA2C Antibody (C-term) with the following immunoassay(s):
Western Blot (WB) (ADRA2C Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ADRA2C antibody detected the ADRA2C protein (arrow).)
Immunohistochemistry (IHC) (ADRA2C Antibody (C-term) (MBS9206885)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ADRA2C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Alpha-2-adrenergic receptors are members of the G
protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
have a critical role in regulating neurotransmitter release from
sympathetic nerves and from adrenergic neurons in the central
nervous system. The mouse studies revealed that both the alpha2A
and alpha2C subtypes were required for normal presynaptic control
of transmitter release from sympathetic nerves in the heart and
from central noradrenergic neurons. The alpha2A subtype inhibited
transmitter release at high stimulation frequencies, whereas the
alpha2C subtype modulated neurotransmission at lower levels of
nerve activity. This gene encodes the alpha2C subtype, which
contains no introns in either its coding or untranslated sequences.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ADRA2C are readily searchable from our website. Different antibodies against the same target such as ADRA2C may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.