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anti-Advanced glycated protein endproduct antibody product blog

Posted on 2016-04-28 06:05:58 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; Advanced glycated protein endproduct; anti-Advanced glycated protein endproduct antibody;
The AGE n/a (Catalog #MBS540613) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AGE Antibody reacts with Bovine, Human, Monkey, Panda and may cross-react with other species as described in the data sheet. MyBioSource\'s AGE can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500. Researchers should empirically determine the suitability of the AGE n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the AGE Antibody with the following immunoassay(s):
Western Blot (WB)
Western Blot (WB) AGE.

Affinity Purified Advance Glycated Endproduct Antibody
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Immunogen: Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37 degree C for several months.
Expression: Endothelial cells. Molecular Function: Inflammatory Response
Structure: Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.
Subcellular Location: Isoform 1 : Cell membrane; Single-pass type I membrane protein
Isoform 2 : Secreted
Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AGE are readily searchable from our website. Different antibodies against the same target such as AGE may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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