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anti-AIFM1 antibody product blog

Posted on 2016-08-21 05:55:07 by mybiosource_staff
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Tags: Antibody; AIF; Polyclonal Antibody; anti-AIFM1 antibody; AIFM1;
The AIFM1 aifm1 (Catalog #MBS176953) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-AIF antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s AIF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC. Researchers should empirically determine the suitability of the AIFM1 aifm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The AIFM1 aifm1 product has the following accession number(s) (GI #13431764) (NCBI Accession #O95831.1) (Uniprot Accession #O95831). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-AIF antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-AIF antibody, MBS176953, IHC(P)
IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC) AIFM1.

Immunohistochemistry (IHC) (Anti-AIF antibody, MBS176953, IHC(P)
IHC(P): Rat Cardiac Muscle Tissue )
Immunohistochemistry (IHC) AIFM1.

Western Blot (WB) (Anti-AIF antibody, MBS176953, Western blotting
Lane 1: Rat Heart Tissue Lysate
Lane 2: Rat Brain Tissue Lysate
Lane 3: K562 Cell Lysate
Lane 4: HEPG2 Cell Lysate
Lane 5: A431 Cell Lysate
Lane 6: NIH3T3 Cell Lysate )
Western Blot (WB) AIFM1.

Description: Rabbit IgG polyclonal antibody for Apoptosis-inducing factor 1, mitochondrial(AIFM1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.
Background: Apoptosis-inducing factor 1, mitochondrial, also known as AIF or PDCD8 is a protein that in humans is encoded by the AIFM1 gene. AIFM1 gene is mapped to Xq26.1 based on an alignment of the AIFM1 sequence with the genomic sequence. This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. A related pseudogene has been identified on chromosome 10.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human AIF (596-613aa EQHEDLNEVAKLFNIHED), identical to the related rat and mouse sequences. Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AIFM1 are readily searchable from our website. Different antibodies against the same target such as AIFM1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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