anti-AKIRIN1 antibody product blog
Tags: Antibody; Polyclonal Antibody; Akirin1; anti-AKIRIN1 antibody; AKIR1;
The AKIRIN1 akirin1 (Catalog #MBS9202961) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AKIR1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s AKIR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).WB~~1:1000. Researchers should empirically determine the suitability of the AKIRIN1 akirin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The AKIRIN1 akirin1 product has the following accession number(s) (GI #210147487) (NCBI Accession #NP_001129747.1) (Uniprot Accession #Q9H9L7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the AKIR1 Antibody (C-term) with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of AKIR1 Antibody (C-term) in Hela cell line lysates (35ug/lane).AKIR1 (arrow) was detected using the purified Pab.)
The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AKIRIN1 are readily searchable from our website. Different antibodies against the same target such as AKIRIN1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Inflammation, Necrosis are some of the diseases may be linked to AKIR1 Antibody (C-term). Brain, Embryonic Tissue, Intestine, Kidney, Muscle, Salivary Gland, Spleen tissues are correlated with this protein.