anti-ALK antibody product blog
Tags: Antibody; Polyclonal Antibody; ALK; anti-ALK antibody;
The ALK alk (Catalog #MBS9406840) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ALK (Phospho-Tyr1096) Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ALK can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC).Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the ALK alk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ALK alk product has the following accession number(s) (GI #29029632) (NCBI Accession #NP_004295.2) (Uniprot Accession #Q9UM73). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ALK (Phospho-Tyr1096) Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human brain tissue, using ALK (Phospho-Tyr1096) antibody (left)or the same antibody preincubated with blocking peptide (right).)
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3\' half of ALK, derived from chromosome 2, is fused to the 5\' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. Morris S.W., Oncogene 14:2175-2188(1997).Morris S.W., Oncogene 15:2883-2883(1997).Iwahara T., Oncogene 14:439-449(1997).
Immunogen Type: Peptide-KLH
Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y(p)-C-F) derived from Human ALK. Modification: Phospho-Tyr1096
Target Name: ALK. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ALK are readily searchable from our website. Different antibodies against the same target such as ALK may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Brain, Connective Tissue, Liver, Muscle, Spleen, Stomach, Testis, Trachea, Uncharacterized Tissue tissues are correlated with this protein. The following patways have been known to be associated with this gene. Carcinoma, Non-Small-Cell Lung, Chromosome Aberrations, Inflammation, Lung Diseases, Lung Neoplasms, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Large-Cell, Anaplastic, Neoplasms, Experimental, Neuroblastoma, Respiratory Tract Diseases are some of the diseases may be linked to ALK (Phospho-Tyr1096) Antibody.