|The APH1B aph1b (Catalog #MBS540981) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Aph 1b Antibody BIOTIN-Conjugated reacts with C. elegans, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Aph 1b can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
Dot Blot: 1:10,000
Western Blot: 1:500. Researchers should empirically determine the suitability of the APH1B aph1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The APH1B aph1b product has the following accession number(s) (GI #61252592) (NCBI Accession #Q8WW43.3) (Uniprot Accession #Q8WW43). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
BIOTIN-Conjugated Presenelin-stabiliziation factor-like Antibody
Subunit of gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and beta-amyloid precursor protein.
Immunogen: Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein.
Expression: Weakly expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle, heart, and brain. Molecular Function: Notch signaling pathway
Structure: Component of gamma-secretase complex. Interacts with PSEN1 and PSEN2.
Subcellular Location: Membrane; Multi-pass protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing APH1B are readily searchable from our website. Different antibodies against the same target such as APH1B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Brain tissues are correlated with this protein. Breast Neoplasms, Cardiovascular Diseases, Cognition Disorders, Disease Models, Animal, Heart Diseases, Learning Disorders, Memory Disorders, Necrosis are some of the diseases may be linked to Aph 1b Antibody BIOTIN-Conjugated. APH1B also interacts with the following gene(s): ADAM10, NCSTN, NOTCH1, PSEN1, PSEN2, PSENEN.