anti-APPBP1 antibody product blog
Tags: Antibody; Polyclonal Antibody; APPBP1; anti-APPBP1 antibody;
The APPBP1 n/a (Catalog #MBS626798) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APPBP1, CT (NEDD8-activating Enzyme E1 Regulatory Subunit, Amyloid Protein-binding Protein 1, Amyloid beta Precursor Protein-binding Protein 1, 59kD, APP-BP1, Proto-oncogene Protein 1, NAE1, HPP1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s APPBP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the APPBP1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the APPBP1, CT (NEDD8-activating Enzyme E1 Regulatory Subunit, Amyloid Protein-binding Protein 1, Amyloid beta Precursor Protein-binding Protein 1, 59kD, APP-BP1, Proto-oncogene Protein 1, NAE1, HPP1) with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of anti-APPBP1 Antibody (C-term) in mouse brain tissue lysates (35ug/lane). APPBP1(arrow) was detected using the purified Pab.)
Western Blot (WB) (Western blot analysis of APP-BP1(arrow) using rabbit polyclonal APP-BP1 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APP-BP1 gene (Lane 2) (Origene Technologies).)
Immunohistochemistry (IHC) (Formalin-fixed and paraffin-embedded human breast carcinoma reacted with anti-APPBP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
APPBP1 binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties thought to play a role in the pathogenesis of Alzheimer\'s disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, an ubiquitin-like protein. APPB1 is required for cell cycle progression through the S/M checkpoint.
Immunogen: Synthetic peptide selected from the C-terminal region of human APPBP1 (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing APPBP1 are readily searchable from our website. Different antibodies against the same target such as APPBP1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.