|The ASC pycard (Catalog #MBS9401386) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ASC Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ASC can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the ASC pycard for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ASC pycard product has the following accession number(s) (GI #10801602) (NCBI Accession #BAA87339). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ASC Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of ASC in HL60 whole cell lysate in the absence (A) or presence (B) of blocking peptide (2287P) with ASC antibody at 1 ug /ml.)
Immunocytochemistry (ICC) (Immunocytochemistry of ASC in HL60 cells with ASC antibody at 5 ug/mL.)
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3, 4). Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
Immunogen Type: Peptide
Immunogen Description: Raised against a synthetic peptide corresponding to amino acids 182 to 195 of human ASC. Target Name: ASC. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ASC are readily searchable from our website. Different antibodies against the same target such as ASC may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. ASC also interacts with the following gene(s): AIM2, CARD8, CASP1, CASP5, MEFV, NLRC4, NLRP1, NLRP3, PSTPIP1, TP53. Adenocarcinoma, Brain Diseases, Colorectal Neoplasms, Disease Models, Animal, Fibrosis, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to ASC Antibody.