anti-Bad antibody product blog
Tags: Antibody; anti-BAD antibody; BAD; Polyclonal Antibody;
The Bad n/a (Catalog #MBS837381) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Bad can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB).IP: 5-20 ug/ml
WB: 1-2 ug/ml. Researchers should empirically determine the suitability of the Bad n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Rabbit polyclonal Phospho-Bad antibody.
Biological Significance: Bad is a member of the Bcl-2 family protein that selectively dimerize with Bcl-xL and Bcl-2 resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that result in the phosphorylation of Bad at Ser112 and Ser 136. Phosphorylation at these sites results in the binding of Bad to 14-3-3 proteins and the inhibition of Bad binding to Bcl-xL and Bcl-2. Recently, Akt has also been shown to promote cell survival via its ability to phosphorylate Bad at Ser136. Cross-Reactivity: Human, Mouse, Rat
Immunogen: Phospho-Bad antibody was raised in Rabbit using synthetic phospho-peptide corresponding to residues surrounding Ser112 of mouse Bad as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Bad are readily searchable from our website. Different antibodies against the same target such as Bad may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.