anti-BCL2L1 antibody product blog
Tags: Antibody; Polyclonal Antibody; BCL2L1; anti-BCL2L1 antibody; Bcl 2 Inhibitor of Transcription 1;
The BCL2L1 bcl2l1 (Catalog #MBS621825) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Bcl 2 Inhibitor of Transcription 1 (Bit1, Peptidyl-tRNA Hydrolase 2) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Bcl 2 Inhibitor of Transcription 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot. Researchers should empirically determine the suitability of the BCL2L1 bcl2l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The BCL2L1 bcl2l1 product has the following accession number(s) (GI #728955) (NCBI Accession #Q07817.1) (Uniprot Accession #Q07817). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process. Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE. Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the ?5?1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the ?5?1 integrin.
Immunogen: Human Bit1 / Bcl-2 inhibitor of transcription 1 / Peptidyl-tRNA hydrolase 2 (IN) peptide. Positive Control: Daudi cell lysate can be used as positive control. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing BCL2L1 are readily searchable from our website. Different antibodies against the same target such as BCL2L1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Vascular tissues are correlated with this protein.