anti-Beta-Catenin CTNNB antibody product blog
Tags: Antibody; Polyclonal Antibody; Beta-Catenin CTNNB; anti-Beta-Catenin CTNNB antibody;
The CTNNB1 ctnnb1 (Catalog #MBS540624) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The beta Catenin Antibody N-epitope reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s beta Catenin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500. Researchers should empirically determine the suitability of the CTNNB1 ctnnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CTNNB1 ctnnb1 product has the following accession number(s) (GI #461854) (NCBI Accession #P35222.1) (Uniprot Accession #P35222). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the beta Catenin Antibody N-epitope with the following immunoassay(s):
Immunohistochemistry (IHC)
Major downstream component of the canonical Wnt signalling pathway. Also involved in the regulation of cell adhesion and acts as a negative regulator of centrosome cohesion.
Immunogen: N-epitope synthetic peptide taken within amino acid region 50-100 on human beta CTNNB protein.
Expression: Expressed in hair follicle cell types including basal and peripheral matrix cells as well as cells of the outer and inner root sheaths. Also expressed in colon and is present in cortical neurons at protein level. Determinant: N-epitope
Molecular Function: Activator; Alpha-catenin binding; Cadherin binding; signal transducer activity
Structure: Two separate complex associated pools found in cytoplasm, majority as compenent of an E-cadheren/catenin adhesion complex. Another cytoplasmic pool is a part of a large complex which holds AXIN1, AXIN2, APC, CSNK1A1 and GSK3B
Subcellular Location: Cytoplasm; Nucleus; Cell junction; Cell Membrane. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CTNNB1 are readily searchable from our website. Different antibodies against the same target such as CTNNB1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Embryonic Tissue, Intestine, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein. Adenocarcinoma, Adenoma, Breast Neoplasms, Carcinoma, Hepatocellular, Colonic Neoplasms, Colorectal Neoplasms, Intestinal Neoplasms, Liver Diseases, Liver Neoplasms, Neoplasm Invasiveness are some of the diseases may be linked to beta Catenin Antibody N-epitope.