anti-BMF antibody product blog
Tags: Antibody; Polyclonal Antibody; BMF; anti-BMF antibody;
The BMF bmf (Catalog #MBS840373) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BMF reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s BMF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).Western blotting (0.5-4 ug/ml) and Immunohistochemistry (5 ug/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~28 kDa BMF in sample from human, mouse and rat origins. Reactivity to other species has not been tested. Researchers should empirically determine the suitability of the BMF bmf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The BMF bmf product has the following accession number(s) (GI #51558688) (NCBI Accession #NP_001003940.1) (Uniprot Accession #Q96LC9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the BMF with the following immunoassay(s):
Testing Data
Background: Bmf (for Bcl-2-modifying factor) is a novel BH3-only protein recently identified in human and mouse. The BH3 domain in Bmf is required for both binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell\'s actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptosis program.
Immunogen: Synthetic peptide surrounding amino acid 9 of human BMF
Positive Control: Western Blot: Jurkat cell lysate and Rat kidney tissue lysate. IHC: Kidney tissue. Handling: The antibody solution should be gently mixed before use. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing BMF are readily searchable from our website. Different antibodies against the same target such as BMF may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Connective Tissue, Heart, Kidney, Liver, Lung, Skin, Vascular tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Fibrosis, Inflammation, Leukemia, Lymphocytic, Chronic, B-Cell, Liver Diseases, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to BMF.