|The Bnip3L bnip3l (Catalog #MBS396006) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Bnip3L (IN) (nix) (bcl 2 family) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Bnip3L (nix) (bcl 2 family) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Bnip3L bnip3l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Bnip3L bnip3l product has the following accession number(s) (GI #4757860) (NCBI Accession #NP_004322.1) (Uniprot Accession #O60238). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Bnip3L (IN) (nix) (bcl 2 family) with the following immunoassay(s):
Western Blot/Blotting (Western blot analysis)
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3, and Nix (for Nip3-like protein X) (1-3). Bnip3L/Bnip3 /Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis (2,3). Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (1,2). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
Immunogen: Synthetic peptide corresponding to amino acids 77 to 92 of the human Bnip3L protein. Immunogen sequence is identical in the mouse protein. Positive Control: K562 cell lysate. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Bnip3L are readily searchable from our website. Different antibodies against the same target such as Bnip3L may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bnip3L also interacts with the following gene(s): BCL2, BCL2L1, BNIP3, CREBBP, ERBB2, HIF1A, TP53.