anti-Bok antibody product blog
Tags: Antibody; BOK; anti-BOK antibody; Polyclonal Antibody;
The Bok n/a (Catalog #MBS840766) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Bok Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Bok can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western blot analysis (0.5-4 ug/ml). Researchers should empirically determine the suitability of the Bok n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Background: Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.
Immunogen: Synthetic peptide surrounding amino acid 44 of rat BOK. Handling: The antibody solution should be gently mixed before use. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Bok are readily searchable from our website. Different antibodies against the same target such as Bok may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.