|The CACNA1A cacna1a (Catalog #MBS9216411) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CACNA1A Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CACNA1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
WB ~~ 1:2000. Researchers should empirically determine the suitability of the CACNA1A cacna1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CACNA1A cacna1a product has the following accession number(s) (GI #148536844) (NCBI Accession #NP_000059.3) (Uniprot Accession #O00555). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CACNA1A Antibody (Center) with the following immunoassay(s):
Western Blot (WB) (All lanes : Anti-CACNA1A Antibody (Center) at 1:2000 dilution
Lane 1: NCI-H1299 whole cell lysate
Lane 2: THP-1 whole cell lysate
Lysates/proteins at 20 ug per lane.
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 282 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.)
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the \'high-voltage activated\' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Antigen Source: Human. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CACNA1A are readily searchable from our website. Different antibodies against the same target such as CACNA1A may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CACNA1A also interacts with the following gene(s): CACNB1, CACNB4, PRKCG, RYR1. Ataxia, Disease Models, Animal, Edema, Epilepsy, Absence, Hemiplegic migraine, familial type 1, MIGRAINE, FAMILIAL HEMIPLEGIC, 1, Neurobehavioral Manifestations, Neurologic Manifestations, Pain, Spinocerebellar Ataxias are some of the diseases may be linked to CACNA1A Antibody (Center). The following patways have been known to be associated with this gene.