anti-CADM1 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-CADM1 antibody; CADM1;
The CADM1 cadm1 (Catalog #MBS9205898) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CADM1 Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CADM1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC).WB~~1:1000. Researchers should empirically determine the suitability of the CADM1 cadm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CADM1 cadm1 product has the following accession number(s) (GI #148664211) (NCBI Accession #NP_001091987.1) (Uniprot Accession #Q9BY67). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CADM1 Antibody (N-term) with the following immunoassay(s):
Western Blot (WB) (CADM1 Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the CADM1 antibody detected the CADM1 protein (arrow).)
Western Blot (WB) (CADM1 Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CADM1 antibody detected the CADM1 protein (arrow).)
Immunohistochemistry (IHC) (CADM1 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CADM1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CADM1 are readily searchable from our website. Different antibodies against the same target such as CADM1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.