|The CASP10 casp10 (Catalog #MBS629243) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CASP10, ID (Caspase-10, CASP-10, ICE-like Apoptotic Protease 4, Apoptotic Protease Mch-4, FAS-associated Death Domain Protein Interleukin-1B-converting Enzyme 2, FLICE2, Caspase-10 Subunit p23/17, Caspase-10 Subunit p12, MCH4) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CASP10 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100. Researchers should empirically determine the suitability of the CASP10 casp10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CASP10 casp10 product has the following accession number(s) (GI #330864823) (NCBI Accession #NP_001193453.1) (Uniprot Accession #Q68HC0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
CASP10 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in the protein are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.
Immunogen: Synthetic peptide selected from the Center region of human CASP10 (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CASP10 are readily searchable from our website. Different antibodies against the same target such as CASP10 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CASP10 also interacts with the following gene(s): BID, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, DEDD, FADD, TRAF1. Adenocarcinoma, Breast Neoplasms, Carcinoma, Leukemia, Lung Diseases, Lung Neoplasms, Necrosis, Neoplasms, Nervous System Diseases, Neuroblastoma are some of the diseases may be linked to CASP10, ID (Caspase-10, CASP-10, ICE-like Apoptotic Protease 4, Apoptotic Protease Mch-4, FAS-associated Death Domain Protein Interleukin-1B-converting Enzyme 2, FLICE2, Caspase-10 Subunit p23/17, Caspase-10 Subunit p12, MCH4).