anti-CASP12 antibody product blog
Tags: Antibody; Polyclonal Antibody; CASP12; anti-CASP12 antibody; Caspase-12;
The CASP12 casp12 (Catalog #MBS176262) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Caspase-12 antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Caspase-12 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the CASP12 casp12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The CASP12 casp12 product has the following accession number(s) (GI #395398427) (NCBI Accession #Q6UXS9.2) (Uniprot Accession #Q6UXS9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Caspase-12 antibody with the following immunoassay(s):
Western Blot (WB) (Anti-Caspase-12 antibody, MBS176262, Western blotting
All lanes: Anti Caspase-12 (MBS176262) at 0.5ug/ml
Lane 1: PANC Whole Cell Lysate at 40ug
Lane 2: SMMC Whole Cell Lysate at 40ug
Lane 3: A549 Whole Cell Lysate at 40ug
Lane 4: HELA Whole Cell Lysate at 40ug
Predicted bind size: 39KD
Observed bind size: 39KD)
Immunohistochemistry (IHC) (Anti-Caspase-12 antibody, MBS176262, IHC(P)
IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC) (Anti-Caspase-12 antibody, MBS176262, IHC(P)
IHC(P): Human Lung Cancer Tissue )
Description: Rabbit IgG polyclonal antibody for Inactive caspase-12(CASP12) detection. Tested with WB, IHC-P in Human.
Background: Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12 (71-84aa KIFREHLWNSKKQL). Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CASP12 are readily searchable from our website. Different antibodies against the same target such as CASP12 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.