|The Casp12 casp12 (Catalog #MBS6001433) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CASP12, ID (CASP12, Inactive caspase-12) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CASP12 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF).
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50
Immunofluorescence: 1:10-50. Researchers should empirically determine the suitability of the Casp12 casp12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Casp12 casp12 product has the following accession number(s) (GI #18426852) (NCBI Accession #NP_569106.1) (Uniprot Accession #Q920D5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
Immunogen: CASP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-201 amino acids from the Central region of human CASP12. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Casp12 are readily searchable from our website. Different antibodies against the same target such as Casp12 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Casp12 also interacts with the following gene(s): Apaf1, Atf6, Capn1, Capn2, Casp1, Casp3, Ddit3, Iapp, Tnf. The following patways have been known to be associated with this gene. Liver tissues are correlated with this protein. Acute Kidney Injury, Brain Diseases, Heart Diseases, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Neoplasms, Nerve Degeneration, Nervous System Diseases are some of the diseases may be linked to CASP12, ID (CASP12, Inactive caspase-12).