|The Casp12 casp12 (Catalog #MBS9401397) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Caspase-12 Antibody (Large) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Caspase-12 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the Casp12 casp12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Casp12 casp12 product has the following accession number(s) (GI #2094806) (NCBI Accession #CAA73532) (Uniprot Accession #O08736). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Caspase-12 Antibody (Large) with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of caspase-12 in human heart lysate with caspase-12 antibody (large) at 0.5 (lane A), 1 (lane B), and 2 ug/mL (lane C), respectively.)
Immunohistochemistry (IHC) (Immunohistochemical staining of human heart tissue using caspase-12 antibody (large) at 2 ug/mL.)
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer\'s disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
Immunogen Type: Peptide
Immunogen Description: Raised against a synthetic peptide corresponding to amino acids within the large cleavage product of murine caspase-12. Target Name: Caspase-12 (Large). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Casp12 are readily searchable from our website. Different antibodies against the same target such as Casp12 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Casp12 also interacts with the following gene(s): Apaf1, Capn1, Capn2, Casp3, Casp9, Iapp, Xiap.