|The CASP14 casp14 (Catalog #MBS9402966) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CASP14 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CASP14 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western blotting: 1:500-1:2000. Researchers should empirically determine the suitability of the CASP14 casp14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CASP14 casp14 product has the following accession number(s) (GI #6912286) (NCBI Accession #NP_036246.1) (Uniprot Accession #P31944). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CASP14 Antibody with the following immunoassay(s):
Testing Data (Gel: 12%SDS-PAGE Lysates (from left to right): Jurkat, A431, A549 and A375 cell Amount of lysate: 40ug per lane Primary antibody: 1/350 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 seconds)
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Immunogen Type: Recombinant Protein
Immunogen Description: Fusion protein corresponding to residues near the N terminal of human caspase 14, apoptosis-related cysteine peptidase. Target Name: CASP14. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CASP14 are readily searchable from our website. Different antibodies against the same target such as CASP14 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CASP14 also interacts with the following gene(s): CASP10, CASP8. Brain Diseases, Breast Neoplasms, Cardiovascular Diseases, Chromosome Aberrations, Inflammation, Necrosis, Neurobehavioral Manifestations, Neurologic Manifestations, Skin Neoplasms, Vascular Diseases are some of the diseases may be linked to CASP14 Antibody.