anti-CASP4 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-CASP4 antibody; CASP4; Caspase 13, aa91-105;
The CASP4 casp13 (Catalog #MBS643192) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Caspase 13, aa91-105 (ERICE) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Caspase 13, aa91-105 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CASP4 casp13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The CASP4 casp13 product has the following accession number(s) (GI #28603750) (NCBI Accession #NP_788811.1) (Uniprot Accession #O75601). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Caspase 13, aa91-105 (ERICE) with the following immunoassay(s):
Testing Data
Testing Data
Testing Data
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13 (1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1).
This polyclonal antibody can be used for detection of AIF by Western blot at 0.5 to 1ug/ml. HL60 cell lysate can be used as positive control and a 43kD band should be detected. It is human, mouse and rat reactive.
Immunogen: Peptide corresponding to amino acids 91 to 105 of human Acaspase-13. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CASP4 are readily searchable from our website. Different antibodies against the same target such as CASP4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. CASP4 also interacts with the following gene(s): ATF6, CASP8. Breast Neoplasms, Carcinoma, Squamous Cell, Cardiovascular Diseases, Gastrointestinal Diseases, Inflammation, Liver Diseases, Lung Diseases, Lung Neoplasms, Necrosis, Neoplasms are some of the diseases may be linked to Caspase 13, aa91-105 (ERICE).