anti-CASP8 antibody product blog
Tags: Antibody; CASP8; Polyclonal Antibody; anti-CASP8 antibody; Caspase8;
The CASP8 casp8 (Catalog #MBS9403426) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Caspase8 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Caspase8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western blotting: 1:500~1:1000. Researchers should empirically determine the suitability of the CASP8 casp8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CASP8 casp8 product has the following accession number(s) (GI #122056474) (NCBI Accession #NP_001073593.1) (Uniprot Accession #Q14790). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Caspase8 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extract from 293, Hela and HT29 cells using Caspase8 Antibody)
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Immunogen Type: Peptide-KLH
Immunogen Description: Peptide sequence around aa.217~221 (S-E-S-Q-T) derived from Caspase 8. Target Name: Caspase-8. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CASP8 are readily searchable from our website. Different antibodies against the same target such as CASP8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Vascular tissues are correlated with this protein. CASP8 also interacts with the following gene(s): CASP10, CFLAR, FADD, FAS, FASLG, RIPK1, TNFRSF10A, TNFRSF10B, TNFSF10, TRAF2.