|The CASP8AP2 casp8ap2 (Catalog #MBS614634) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FLASH, CT (FLICE-associated Huge Protein) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s FLASH can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA, Western Blotting.
Dilution: Western Blotting: 0.25-1ug/ml. Researchers should empirically determine the suitability of the CASP8AP2 casp8ap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CASP8AP2 casp8ap2 product has the following accession number(s) (GI #6090856) (Uniprot Accession #Q9UKL3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2). FLASH is widely expressed.
Immunogen: Raised against a synthetic peptide (SERFQQLMKLFEKSKC) corresponding to amino acids 1253 to 1268 of human origin, which differ from those of mouse by one amino acid (1,2). Positive Control: HeLa whole cell lysate. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CASP8AP2 are readily searchable from our website. Different antibodies against the same target such as CASP8AP2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CASP8AP2 also interacts with the following gene(s): CASP8, FADD, FAS, SP100, TRAF2. The following patways have been known to be associated with this gene. Cardiovascular Diseases, Chromosome Aberrations, Colorectal Neoplasms, Leukemia, Leukemia, T-Cell, Necrosis, Neoplasms, Nervous System Diseases, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Vascular Diseases are some of the diseases may be linked to FLASH, CT (FLICE-associated Huge Protein). Blood, Bone, Bone Marrow, Brain, Eye, Heart, Muscle, Thyroid tissues are correlated with this protein.