|The CBLC cblc (Catalog #MBS627246) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CBL-C, NT (Signal Transduction Protein CBL-C, SH3-binding Protein CBL-C, SH3-binding Protein CBL-3, CBL3, RING Finger Protein 57, RNF57) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CBL-C can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the CBLC cblc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CBLC cblc product has the following accession number(s) (GI #6291532) (Uniprot Accession #Q9ULV8). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Immunogen: Synthetic peptide selected from the N-terminal region of human Cbl-c (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CBLC are readily searchable from our website. Different antibodies against the same target such as CBLC may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CBLC also interacts with the following gene(s): EGFR, ITCH, SRC. Brain, Lung, Mammary Gland, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Cell Transformation, Neoplastic, Craniofacial Abnormalities, Lung Neoplasms, Neural Tube Defects, Neurodegenerative Diseases, Neurologic Manifestations, Retinal Degeneration, Seizures are some of the diseases may be linked to CBL-C, NT (Signal Transduction Protein CBL-C, SH3-binding Protein CBL-C, SH3-binding Protein CBL-3, CBL3, RING Finger Protein 57, RNF57).