|The CCNH ccnh (Catalog #MBS9409263) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cyclin H (Phospho-Thr315) Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Cyclin H can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western blotting: 1:500~1:1000. Researchers should empirically determine the suitability of the CCNH ccnh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CCNH ccnh product has the following accession number(s) (GI #4502623) (NCBI Accession #NP_001230.1) (Uniprot Accession #P51946). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Cyclin H (Phospho-Thr315) Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from JK cells (Lane 2), using Cyclin H (Phospho-Thr315) Antibody. The lane on the left is treated with antigen-specific peptide.)
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.Maekelae T.P., Nature 371:254-257(1994).Fisher R.P., Cell 78:713-724(1994).The MGC Project Team; Genome Res. 14:2121-2127(2004).
Immunogen Type: Peptide-KLH
Immunogen Description: Peptide sequence around phosphorylation site of threonine 315 (E-W-T(p)-D-D) derived from Human Cyclin H. Modification: Phospho-Thr315
Target Name: Cyclin H. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CCNH are readily searchable from our website. Different antibodies against the same target such as CCNH may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CCNH also interacts with the following gene(s): CDK2, CDK4, CDK7, ERCC2, GTF2E1, MNAT1. The following patways have been known to be associated with this gene.