anti-CCR8 antibody product blog
Tags: Antibody; Polyclonal Antibody; CCR8; anti-CCR8 antibody;
The CCR8 ccr8 (Catalog #MBS6004131) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CCR8, CT (CCR8, CKRL1, CMKBR8, CMKBRL2, C-C chemokine receptor type 8, CC chemokine receptor CHEMR1, Chemokine receptor-like 1, GPR-CY6, TER1, CDw198) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CCR8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS).Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50. Researchers should empirically determine the suitability of the CCR8 ccr8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CCR8 ccr8 product has the following accession number(s) (GI #4885121) (NCBI Accession #NP_005192.1) (Uniprot Accession #P51685). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CCR8, CT (CCR8, CKRL1, CMKBR8, CMKBRL2, C-C chemokine receptor type 8, CC chemokine receptor CHEMR1, Chemokine receptor-like 1, GPR-CY6, TER1, CDw198) with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis in MDA-MB435 cell line lysates (35ug/lane) using MBS6004131. This demonstrates that MBS6004131 detected the CCR8 protein (arrow).)
Flow Cytometry (FC/FACS) (Flow Cytometric analysis of MDA-MB435 cells using MBS6004131 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. CCR8 is located at the chemokine receptor gene cluster region.
Immunogen: CCR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-325 amino acids from the C-terminal region of human CCR8. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CCR8 are readily searchable from our website. Different antibodies against the same target such as CCR8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.