anti-CD105/Endoglin antibody product blog
Tags: Antibody; Polyclonal Antibody; CD105/Endoglin; anti-CD105/Endoglin antibody;
The CD105/Endoglin eng (Catalog #MBS691432) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Anti-Mouse CD105/Endoglin reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CD105/Endoglin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS).ELISA: Use 1-15 ug/ml Western Blot: Use 1-5 mg/ml FACS Use at 3-20 ug/ml. Researchers should empirically determine the suitability of the CD105/Endoglin eng for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD105/Endoglin eng product has the following accession number(s) (GI #226437647) (NCBI Accession #NP_000109) (Uniprot Accession #P17813). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit Anti-Mouse CD105/Endoglin with the following immunoassay(s):
Testing Data
Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human Endoglin, the S-Endoglin and L-Endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse Endoglin share approximately 70% and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human Endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for Endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.
Immunogen: Recombinant mouse sCD105/Endoglin (RT #S01-023)
Preparation: Produced from sera of rabbits pre-immunized with highly pure recombinant mouse soluble CD105/Endoglin (Glu26-Leu581) derived from insect cells. Buffer: PBS. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD105/Endoglin are readily searchable from our website. Different antibodies against the same target such as CD105/Endoglin may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.