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anti-CD278/ICOS antibody product blog

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Posted on 2015-08-02 14:21:32 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; CD278/ICOS; anti-CD278/ICOS antibody;
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The CD278/ICOS icos (Catalog #MBS301743) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Anti-Human CD278/ICOS Polyclonal Antibody reacts with Human
Predicted Reactivity: Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s CD278/ICOS can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin.
Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 1mM EDTA, pH 8.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:100
IHC Positive Control: Tonsil. Researchers should empirically determine the suitability of the CD278/ICOS icos for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The CD278/ICOS icos product has the following accession number(s) (GI #15029518) (NCBI Accession #NP_036224.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit Anti-Human CD278/ICOS Polyclonal Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Human tonsil stained with anti-CD278/ICOS antibody)
Immunohistochemistry (IHC) CD278/ICOS.

CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. It enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. It is essential both for efficient interaction between T and B cells and for normal antibody responses to T cell dependent antigens. It does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. CD278 prevents the apoptosis of pre-activated T cells and it plays a critical role in CD40-mediated class switching of immunoglobin isotypes (by similarity).

Immunogen: Synthetic peptide derived from near C-terminus of human CD278 protein.
Control Tissue: Tonsil
Cellular Localization: Membrane
Entrez Gene Code: 29851
Pathway: Lymphocyte Signaling. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD278/ICOS are readily searchable from our website. Different antibodies against the same target such as CD278/ICOS may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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