|The CD46 cd46 (Catalog #MBS9405146) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD46 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CD46 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
Immunofluorescence: 1:50 - 1:200. Researchers should empirically determine the suitability of the CD46 cd46 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD46 cd46 product has the following accession number(s) (GI #27502402) (NCBI Accession #NP_002380.3) (Uniprot Accession #P15529). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CD46 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of various cell lines, using CD46 antibody.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human kidney using CD46 antibody at dilution of 1:200 (200x lens).)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded rat lung using CD46 antibody at dilution of 1:200 (200x lens).)
Immunofluorescence (IF) (Immunofluorescence analysis of HepG2 cell using CD46 antibody. Blue: DAPI for nuclear staining.)
CD46 is a type I membrane protein and a regulatory part of the complement system. This protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, CD46 can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, this protein may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 is found in a cluster on chromosome 1q32 with other proteins that are structural components of the complement system.
Immunogen Type: Recombinant Protein
Immunogen Description: Recombinant protein of human CD46. Target Name: CD46. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD46 are readily searchable from our website. Different antibodies against the same target such as CD46 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CD46 also interacts with the following gene(s): C4A, CD59, CFI, CR1, SLAMF1.