|The CD80 / B7-1 n/a (Catalog #MBS355088) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD80 / B7-1 antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CD80 / B7-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
WB (1:500). Researchers should empirically determine the suitability of the CD80 / B7-1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD80 / B7-1 n/a product has the following accession number(s) (GI #68163383) (NCBI Accession #NP_001020134.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-CD80 / B7-1 antibody with the following immunoassay(s):
Western Blot (WB)
Cluster of Differentiation 80 (CD80), also called B-lymphocyte activation antigen B7-1 (formerly referred to as B7), is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. The B7-related molecules CD80 and CD86 are expressed on antigen-presenting cells, bind the homologous T cell receptors CD28 and CTLA-4, and trigger costimulatory signals important for optimal T cell activation. All four molecules are immunoglobulin superfamily members, each comprising an extracellular Ig variable-like (IgV) domain, with CD80 and CD86 containing an additional Ig constant-like (IgC) domain.1 The upregulation of B7-1 in podocytes may contribute to the pathogenesis of proteinuria by disrupting the glomerular filter and provides a novel molecular target to tackle proteinuric kidney diseases. This suggests that B7-1 has a novel function in danger signaling by nonimmune cells.2.
Immunogen: A synthetic peptide (conjugated to KLH) corresponding to extracellular region of human CD80 / B7-1. Storage Buffer: In TBS (pH7.4), 0.5% BSA, 25% Glycerol and 0.05% Sodium Azide
Storage Buffer: In TBS (pH7.4), 0.5% BSA, 25% Glycerol and 0.05% Sodium Azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD80 / B7-1 are readily searchable from our website. Different antibodies against the same target such as CD80 / B7-1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.