|The CD8A cd8a (Catalog #MBS6013046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD8A, CT (T-cell Surface Glycoprotein CD8 alpha Chain, T-lymphocyte Differentiation Antigen T8/Leu-2, MAL) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CD8A can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC).
Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml. Researchers should empirically determine the suitability of the CD8A cd8a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD8A cd8a product has the following accession number(s) (GI #19344022) (NCBI Accession #AAH25715.1) (Uniprot Accession #P01732). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.
Immunogen: Synthetic peptide corresponding to aa from human CD8 at C-terminal (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD8A are readily searchable from our website. Different antibodies against the same target such as CD8A may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Brain, Connective Tissue, Intestine, Kidney, Liver, Lung, Spleen, Stomach, Thymus tissues are correlated with this protein. The following patways have been known to be associated with this gene. CD8A also interacts with the following gene(s): CD3D, CD3E, CD4, CD8B, HLA-A, HLA-B, LCK.