|The CDK4 cdk4 (Catalog #MBS395553) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The cyclin dependent kinase 4 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s cyclin dependent kinase 4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the CDK4 cdk4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CDK4 cdk4 product has the following accession number(s) (GI #4502735) (NCBI Accession #NP_000066.1) (Uniprot Accession #P11802). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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p34cdk4 is a major catalytic subunit of mammalian D-type cyclins which is expressed by a gene found in human chromosome 12q13. The cdk4 protein is constitutively expressed throughout the cell cycle and it is the assembly and accumulation of functional cdk4/cyclin D complexes which is rate limiting for the progression through the G1 phase of the cell cycle. Once the complex is formed it must be activated by the phosphorylation of threonine 172 on the cdk4 subunit, a reaction mediated by a cdk-activating kinase (CAK). Complex formation and phosphorylation are independently regulated events. The phosphorylation of the cdk4 subunit is subject to regulation of both stimulatory and inhibitory cytokine signals, thereby allowing cdk4 to function as a mid G1 checkpoint. Independent of phosphorylation, cdk4 is also regulated by the binding of p16Ink4/mts1 while in complex with cyclin D.
Immunogen: TrpE-fusion protein containing the C-terminal 164 amino acids of human Cdk4. Positive Control: HeLa cell lysate. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CDK4 are readily searchable from our website. Different antibodies against the same target such as CDK4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CDK4 also interacts with the following gene(s): CCNA2, CCND1, CCND2, CCND3, CCNE1, CDC37, CDKN1A, CDKN1B, CDKN2A, RB1. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Liver Diseases, Lung Neoplasms, Neoplasms, Neoplasms, Experimental, Nervous System Diseases, Skin Neoplasms are some of the diseases may be linked to cyclin dependent kinase 4. The following patways have been known to be associated with this gene.