anti-CDKL5 antibody product blog
Tags: Antibody; Polyclonal Antibody; Cdkl5; anti-CDKL5 antibody; CDKL5 (STK9);
The CDKL5 cdkl5 (Catalog #MBS9213332) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CDKL5 (STK9) Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CDKL5 (STK9) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC).WB~~1:1000. Researchers should empirically determine the suitability of the CDKL5 cdkl5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CDKL5 cdkl5 product has the following accession number(s) (GI #83367069) (NCBI Accession #NP_001032420.1) (Uniprot Accession #O76039). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CDKL5 (STK9) Antibody (C-term) with the following immunoassay(s):
Western Blot (WB) (The anti-STK9 Pab is used in Western blot to detect STK9 in mouse lung tissue lysate.)
Immunohistochemistry (IHC) (Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with STK9 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CDKL5 are readily searchable from our website. Different antibodies against the same target such as CDKL5 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Abnormalities, Drug-Induced, Angelman Syndrome, Congenital Abnormalities, Epileptic Encephalopathy, Early Infantile, 2, Lung Diseases, Rett Syndrome, Seizures are some of the diseases may be linked to CDKL5 (STK9) Antibody (C-term).