|The CDKN1B cdkn1b (Catalog #MBS9203123) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The p27Kip1 Antibody (N-term S12) reacts with Human, mouse (Predicted Reactivity: Hamster) and may cross-react with other species as described in the data sheet. MyBioSource\'s p27Kip1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).
WB~~1:1000. Researchers should empirically determine the suitability of the CDKN1B cdkn1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CDKN1B cdkn1b product has the following accession number(s) (GI #4757962) (NCBI Accession #NP_004055.1) (Uniprot Accession #P46527). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the p27Kip1 Antibody (N-term S12) with the following immunoassay(s):
Western Blot (WB) (p27Kip1 Antibody (N-term S12) western blot analysis in A431,Hela,mouse C2C12 cell line lysates (35ug/lane).This demonstrates the p27Kip1 antibody detected the p27Kip1 protein (arrow).)
This gene encodes a cyclin-dependent kinase inhibitor,
which shares a limited similarity with CDK inhibitor CDKN1A/p21.
The encoded protein binds to and prevents the activation of cyclin
E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle
progression at G1. The degradation of this protein, which is
triggered by its CDK dependent phosphorylation and subsequent
ubiquitination by SCF complexes, is required for the cellular
transition from quiescence to the proliferative state. [provided by
Antigen Type: Synthetic Peptide
Crown Antibody: Yes. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CDKN1B are readily searchable from our website. Different antibodies against the same target such as CDKN1B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CDKN1B also interacts with the following gene(s): AKT1, CCNA2, CCND1, CCND3, CCNE1, CDK2, CDK4, CDK6, SKP2, UBC. Adenocarcinoma, Breast Neoplasms, Hyperplasia, Intestinal Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases, Prostatic Neoplasms are some of the diseases may be linked to p27Kip1 Antibody (N-term S12). The following patways have been known to be associated with this gene.