|The CHEK2 chek2 (Catalog #MBS646355) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CHEK2, NT (CHEK2, CDS1, CHK2, RAD53, Rad53 homolog, Checkpoint kinase 2) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s CHEK2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in ELISA, Western Blot, Immunohistochemistry.
Dilution: ELISA: 1:10,000
Western Blot: 1:500-1:1000
Immunohistochemistry (Paraffin): 10ug/ml. Researchers should empirically determine the suitability of the CHEK2 chek2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CHEK2 chek2 product has the following accession number(s) (GI #47678367) (NCBI Accession #CAG30304.1) (Uniprot Accession #O96017). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
CHK2 is a serine/threonine kinase in the CDS subfamily that is activated in response to DNA damage and may regulate cell cycle arrest. It is the human homolog of RAD53 in S. cerevisiae and CDS1 in S. pombe. The protein has a FHA domain, which means it is located in the nucleus. Its kinase activity is up regulated by autophosphorylation in response to DNA damage and to replication blocks. It controls cell cycle checkpoint and may participate in transduction of the DNA damage and replicational stress signals. It also inhibits CDC25 phosphatase to prevent the cell entry into mitosis. Studies show that the deficiency of CHK2 may cause Li-Fraumeni syndrome and other human cancers, such as breast cancer via other gene\'s function.
Immunogen: Synthetic peptide corresponding to human CHEK2/CHK2 at N-Terminal. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CHEK2 are readily searchable from our website. Different antibodies against the same target such as CHEK2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Adenocarcinoma, Breast Neoplasms, Breast Neoplasms, Male, Colorectal Neoplasms, Li-Fraumeni Syndrome, Neoplasms, Neoplasms, Experimental, Nervous System Diseases, Ovarian Neoplasms, Prostatic Neoplasms are some of the diseases may be linked to CHEK2, NT (CHEK2, CDS1, CHK2, RAD53, Rad53 homolog, Checkpoint kinase 2). The following patways have been known to be associated with this gene.