|The CKM ckm (Catalog #MBS6001498) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CKMM, NT (Creatine Kinase M-type, Creatine Kinase M Chain, M-CK, CKM) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CKMM can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500. Researchers should empirically determine the suitability of the CKM ckm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CKM ckm product has the following accession number(s) (GI #21536288) (NCBI Accession #NP_001815.2) (Uniprot Accession #P06732). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. The CKM isoform, predominant in skeletal muscle and heart tissue, is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. CKM reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.
Immunogen: Synthetic peptide selected from the N-terminal region of human CKM (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CKM are readily searchable from our website. Different antibodies against the same target such as CKM may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CKM also interacts with the following gene(s): CKB. The following patways have been known to be associated with this gene. Brain Diseases, Cardiomyopathies, Heart Diseases, Inflammation, Ischemia, Kidney Diseases, Liver Diseases, Myocardial Infarction, Neoplasm Metastasis, Neoplasms are some of the diseases may be linked to CKMM, NT (Creatine Kinase M-type, Creatine Kinase M Chain, M-CK, CKM). Brain, Embryonic Tissue, Eye, Heart, Kidney, Liver, Lung, Muscle, Nerve, Vascular tissues are correlated with this protein.