|The CLCN7 clcn7 (Catalog #MBS611101) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CLC7 (Clcn7, Chloride Channel) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CLC7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA, Western Blot.
Dilution: Western Blot: 1-10ug/ml (ECL.)
ELISA: 0.5-1ug/ml Control peptide can be used to coat ELISA plates at 1ug/ml. Researchers should empirically determine the suitability of the CLCN7 clcn7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CLCN7 clcn7 product has the following accession number(s) (GI #83318378) (Uniprot Accession #Q2VPA2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Voltage-gated chloride channels regulate cellular traffic of chloride ion. The chloride channels (CIC or CLC) performs several functions including the regulation of cell volume, membrane potential stabilization, signal transduction, and transepithelial transport. Mutations in CIC genes have been linked with several human diseases including myotonias (Thomsen\'s disease), cystic fibrosis, Bartters syndrome type III, Dent\'s disease, and X-linked recessive nephrolithiasis. In mammals, CLC proteins form a superfamily of at least 9 different genes (CLC1-7 also known as CLCN1-7 and CLK1-2 or CLCKa and CLCKb). Additional forms of these proteins are obtained by alternative splicing. All CLC proteins (~700-1000 aa) are predicted to contain 10 (possibly 12) transmembrane domains. Except CLC-1 and CLC-K1/K2 that are specific for kidney, most other CLC are widely distributed in various tissues. Rat CLC-7 is 802 aa membrane protein (mouse 803 aa, human 805 aa) (1). CLC-7 has a calculated MW of approx. 90kD. CLC-7 is ~45% identical with CLC-6. CLC-7 is expressed in brain, tested, muscle and kidney (1).
Immunogen: A 15 AA Peptide sequence near the N-terminus of human CLC-7 (1) was coupled to KLH. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CLCN7 are readily searchable from our website. Different antibodies against the same target such as CLCN7 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Anemia, Atrophy, Brain Diseases, Kidney Diseases, Lung Diseases, Necrosis, OSTEOPETROSIS, AUTOSOMAL RECESSIVE 4, Osteopetrosis, Seizures, Thrombocytopenia are some of the diseases may be linked to CLC7 (Clcn7, Chloride Channel).