|The CNGA1 cnga1 (Catalog #MBS613330) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CNG1 (Cyclic Nucleotide-Gated Channels 1) reacts with Human, Porcine and may cross-react with other species as described in the data sheet. MyBioSource\'s CNG1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.5-1ug/ml Control peptide (C5999-25) can be used to coat ELISA plates at 1ug/ml.
Western Blot: 1-10ug/ml using ECL. Researchers should empirically determine the suitability of the CNGA1 cnga1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CNGA1 cnga1 product has the following accession number(s) (GI #217035093) (NCBI Accession #NP_001136036.1) (Uniprot Accession #P29973). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The cyclic nucleotides cAMP and cGMP are implicated in signal transduction events such as the visual transduction, relaxation of smooth muscles, intestinal secretion of water and salt, reabsorption of Na+ and water in the distal tubule of the nephrons. cAMP/cGMP activate Ca2+ -permeable ion channels called cyclic nucleotide-gated channels (CNG or CNC). Activation of CNG leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+. CNG consists of two distinct subunits, designated an and b subunits. Several CNG a-subunits (CNG alpha 1-3) & beta subunits (subunit 2 or CNGb1-2 or CNG4-5) and numerous isoforms. a-subunit can form functional channel by themselves, whereas, b-subunits modulate the channel property of a-subunits. CNG display intracellular N and C-termini, 6 transmembrane domains or segments (S1-S6). The region between S5 and S6 contains the ion-conducting pore (P). The cyclic nucleotide-binding region is found at the c-terminus. Native functional CNG may exists as heteromultimer containing some combination of a, and b subunits.
Immunogen: A 20aa peptide sequence near C-terminus of Human CNG1.
Species Sequence Homology: Porcine. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CNGA1 are readily searchable from our website. Different antibodies against the same target such as CNGA1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.