anti-COL4A1 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-COL4A1 antibody; COL4A1; Collagen IV;
The COL4A1 col4a1 (Catalog #MBS177103) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Collagen IV Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Collagen IV can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the COL4A1 col4a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The COL4A1 col4a1 product has the following accession number(s) (GI #125987809) (NCBI Accession #P02462.3) (Uniprot Accession #P02462). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Collagen IV Antibody with the following immunoassay(s):
Testing Data (Anti-Collagen IV Picoband antibody, MBS177103-1.jpg
All lanes: Anti Collagen IV (MBS177103) at 0.5ug/ml
WB: Recombinant Human Collagen IV Protein 0.5ng
Predicted bind size: 39KD
Observed bind size: 39KD )
Immunohistochemistry (IHC) (Anti-Collagen IV Picoband antibody, MBS177103-2.JPG
IHC(P): Human Lung Cancer Tissue )
Description: Rabbit IgG polyclonal antibody for Collagen alpha-1(IV) chain(COL4A1) detection. Tested with WB, IHC-P in Human.
Background: COL4A1, also known as ICH or Collagen alpha-1(IV), is a protein that in humans is encoded by the COL4A1 gene. It is mapped to 13q34. This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. COL4A1 binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. It is also a potential therapeutic candidate for targeting tumor angiogenesis.
Immunogen: E Coli-derived human Collagen IV recombinant protein (Position: G1445-T1669). Human Collagen IV shares 97% amino acid (aa) sequence identity with mouse Collagen IV. Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing COL4A1 are readily searchable from our website. Different antibodies against the same target such as COL4A1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.