anti-Corneodesmosin antibody product blog
Tags: Antibody; Polyclonal Antibody; Corneodesmosin; anti-Corneodesmosin antibody;
The Corneodesmosin n/a (Catalog #MBS624321) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The Corneodesmosin (CDSN, S Protein) (Biotin) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Corneodesmosin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot.
Dilution: Western Blot: 0.1-0.2ug/ml. Researchers should empirically determine the suitability of the Corneodesmosin n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Corneodesmosin n/a product has the following accession number(s) (GI #9937327). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
CDSN (Corneodesmosin; also S protein) is a 52-56kD, secreted glycoprotein that has an unusually high content of Gly, Pro and Ser. It is found in the desmosomes of spinous layer keratinocytes, and presumably uses its high Gly content to generate homophilic noncovalent intercellular bridges. Mature human CDSN is 497aa in length. It contains a Ser-rich region (aa62-464) and one Gly-rich domain (aa60-171). CDSN undergoes sequential proteolytic processing to generate multiple fragments that vary in size from 46-43kD, to 35-30kD, to 15kD. This sequential extracellular processing allows initially for CDSN incorporation into a functional adhesional junction, and later for the removal of adhesional glycine loops with a subsequent dissociation (desquamation) of cells. There is one potential isoform termed the S protein that shows a two aa substitution for the C-terminal 29aa. Over aa33-529, human CDSN shares 68% aa identity with mouse CDSN.
Immunogen: Purified, NS0-derived, recombinant human Corneodesmosin (aa33-529; Accession # NP_001255, with a Ser153 deletion). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Corneodesmosin are readily searchable from our website. Different antibodies against the same target such as Corneodesmosin may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Corneodesmosin also interacts with the following gene(s): FLNA. Bone, Brain, Connective Tissue, Ear, Embryonic Tissue, Heart, Kidney, Muscle, Umbilical Cord, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.