|The CSF1R csf1r (Catalog #MBS615353) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD115, phosphorylated (Tyr809) (c-fms, Fms, CSF-1R, M-CSFR) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CD115 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000. Researchers should empirically determine the suitability of the CSF1R csf1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CSF1R csf1r product has the following accession number(s) (GI #28833091) (NCBI Accession #AAH47521.1) (Uniprot Accession #P07333). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. MCSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage (1-3). Binding of M-CSF to its receptor induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins (4). There are at least five major tyrosine autophosphorylation sites. Tyrosine 723 (Tyr721 in mouse) is located in the kinase insert (KI) region. Phosphorylated tyrosine 723 binds the p85 subunit of PI3 kinase as well as PLC-gamma2 (5). Phosphorylation of Tyr809 in the receptor provides a docking site for Shc adaptor protein (5). Overactivation of this receptor can lead to a malignant phenotype in various cell systems (6). The activated M-CSF receptor has been shown to be a predictor of poor outcome in advanced epithelial ovarian carcinoma (7) and breast cancer (8).
Immunogen: Synthetic peptide corresponding to residues around Tyr809 of human M-CSF receptor (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CSF1R are readily searchable from our website. Different antibodies against the same target such as CSF1R may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CSF1R also interacts with the following gene(s): CBL, CSF1, ETS1, GRB2, IL34, ITGB3, MYB, PIK3R1, RASA1, SPI1. The following patways have been known to be associated with this gene.